Manuscripts dealing with the development and evaluation of performance of methods and instruments should discuss chemical sensitivity and specificity, detection limits, precision, accuracy, recovery, interference, comparison with other analytical methods ,and normal range, and when appropriate should include clinical data.
Linear regression analysis is a commonly used technique in analyzing method comparison data. If a linear relationship between the test and reference method can be defined, then the slope and intercept of this line can provide estimates of the proportional and constant error between the two methods. However if the basic assumptions underlying the least-squares model are not met, the estimated line may be incorrect.
The Syncron CX5, a random access type analyser used for routine clinical chemistry determinations, was compared to the Gilford 203 S. The analysis of data obtained by running serum samples in parallel on two instruments indicates that the Beckman CX5 correlates with the Gilford 203 S although there were some bias.
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